COMPANY Management Team Scientific Advisors News Careers TECHNOLOGY nanoIR FAQ-nanoIR nano-TA HT-AFM PRODUCTS nanoIR nano-TA2 SThM VESTA Probes APPLICATIONS nanoscale IR Spectroscopy nanoscale Thermal Analysis SUPPORT Applications Lab Manual Technical Notes Released Software EVENTS Conferences and Tradeshows Webinars CONTACT Request Information Sales Contacts Location Applications     Polymers     Pharmaceuticals Pharmaceutical Applications. Application Notes Nano-Structure Properties of a Drug Release Coating (pdf format) Nanoscale thermal analysis of Medical Devices and Implants Listed below are publications that are representative of the applications that have been proved so far using Local Thermal Analysis on Pharmaceutical samples. All of these results are based on micro-TA (using the old Wollaston probe). We are working on publishing our newresults using nano-TA and if you’d like some info on these even before we publish them, please contact us at roshan@anasysinstruments.com Publications a. Peer-reviewed Journals: “Nanoscale thermal analysis of pharmaceutical solid dispersions”, Zhang J, Bunker M, Chen X, Parker AP, Patel N, Roberts CJ, International Journal of Pharmaceutics, July 2009 “Thermomechanical Manipulation of Aromatic Peptide Nanotubes”, Victoria L. Sedman, Stephanie Allen, Xinyong Chen, Clive J. Roberts, and Saul J. B. Tendler Langmuir 2009, 25(13), 7256–7259 “Mapping amorphous material on a partially crystalline surface: Nanothermal analysis for simultaneous characterisation and imaging of lactose compacts”, Xuan Dai, Mike Reading , Duncan Q.M. Craig, Journal of Pharmaceutical Sciences, 2008, Volume 98 Issue 4, Pages 1499-1510 Nanoscale Characterisation and Imaging of Partially Amorphous Materials using Local Thermomechanical Analysis and Heated Tip AFM, Ljiljana Harding, William P. King, Xuan Dai, Duncan Q. M. Craig, and Mike Reading, Pharmaceutical Research, Volume 24, Number 11 / November, 2007, Pages 2048-2054 “Two- and Three-Dimensional Imaging of Multicomponent Systems Using Scanning Thermal Microscopy and Localized Thermomechanical Analysis” Ljiljana Harding, John Wood, Mike Reading, and Duncan Q. M. Craig, Anal. Chem., 2007, 79 (1), pp 129–139 “The development of heated tip force-distance measurements as a novel approach to site-specific characterization of pharmaceutical materials”, Ljiljana Harding, Mike Reading, Duncan Q.M. Craig, Journal of Pharmaceutical Sciences, 2007, Volume 97 Issue 7, Pages 2768-2779 “The development of thermally assisted particle manipulation and thermal nanointeraction studies as a means of investigating drug-polymer interactions”, Ljiljana J. Harding, Mike Reading , Duncan Q.M. Craig, Journal of Pharmaceutical Sciences, 2007, Volume 97 Issue 4, Pages 1551-1563 “Calorimetric and spatial characterization of polymorphic transitions in caffeine using quasi-isothermal MTDSC and localized thermomechanical analysis” Radhesh Manduva , Vicky L. Kett , Simon R. Banks , John Wood , Mike Reading, Journal of Pharmaceutical Sciences, 2007, Volume 97 Issue 3, Pages 1285-1300 "Micro- and Macrothermal Analysis of a Bioactive Surface-Engineered Polymer Formed by Physical Entrapment of Poly(ethylene glycol) into Poly(lactic acid)", Jianxin Zhang, Clive J. Roberts, K. M. Shakesheff, Martyn C. Davies, and Saul J. B. Tendler, Macromolecules 2003, 36, 1215-1221 "Identification of Phase Separation in Solid Dispersions of Itraconazole and Eudragit_ E100 Using Microthermal Analysis", Karel Six, John Murphy, Ilse Weuts, Duncan Q. M. Craig, Geert Verreck, Jef Peeters, Marcus Brewster, and Guy Van den Mooter, Pharmaceutical Research, Vol. 20, No. 1, January 2003, pp. 135-138 "Differential scanning calorimetry and scanning thermal microscopy analysis of pharmaceutical materials", Laura Bond, Stephanie Allen , Martyn C. Davies , Clive J. Roberts, Arif P. Shivji , Saul J.B. Tendler , Phillip M. Williams, Jianxin Zhang, International Journal of Pharmaceutics 243 (2002) 71-82 "Pharmaceutical Applications of Micro-thermal analysis", D. Q. M. Craig, V. L. Kett, C. S. Andrews, and P. G. Royall, Journal of Pharmaceutical Sciences, Vol 91, 1201-1213 (2002) "The use of micro-thermal analysis as an means of in-situ characterization of a tablet coat", P. G. Royall, D. B. Grandy, D. Q. M. Craig, Thermochemica Acta 380 (2001) pp. 165-173 "Identification of Crystalline and Amorphous Regions in Low Molecular Weight Materials Using Microthermal Analysis", P. G. Royall, V. L. Kett, C. S. Andrews, and D. Q. M. Craig, J. Phys. Chem. B 2001, 105, 7021-7026 "An Investigation into the Surface Deposition of Progesterone on Poly(d, l-) Lactic Acid Microspheres Using Micro-Thermal Analysis", Paul G. Royall, Vivienne L. Hill, Duncan Q. M. Craig, Duncan M. Price, and Mike Reading, Pharmaceutical Research, Vol. 18, No. 3, 2001, pp. 294-298 "Discrimination of polymorphic forms of a drug product by localized thermal analysis", G. H. W. SANDERS*¹, C. J. ROBERTS*², A. DANESH*, A. J. MURRAY³, D. M. PRICE§, M. C. DAVIES*, S. J. B. TENDLER* & M. J. WILKINS, Journal of Microscopy, Vol. 198, Pt 2, May 2000, pp. 77-81 b. Non Peer-reviewed: 1. “Micro and nanothermal Analysis of Pharma Materials”, Innovations in Pharmaceutical Techniques, Dec 2006 (pdf format)    © 2010 Anasys Instruments Corporation. All rights reserved.